1pq0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1pq0.jpg|left|200px]]
[[Image:1pq0.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1pq0 |SIZE=350|CAPTION= <scene name='initialview01'>1pq0</scene>, resolution 2.20&Aring;
+
The line below this paragraph, containing "STRUCTURE_1pq0", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= BCL2L1 OR BCL2L OR BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1pq0| PDB=1pq0 | SCENE= }}
-
|RELATEDENTRY=[[1pq1|1PQ1]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pq0 OCA], [http://www.ebi.ac.uk/pdbsum/1pq0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pq0 RCSB]</span>
+
-
}}
+
'''Crystal structure of mouse Bcl-xl'''
'''Crystal structure of mouse Bcl-xl'''
Line 30: Line 27:
[[Category: Marrack, P.]]
[[Category: Marrack, P.]]
[[Category: Zhu, Y.]]
[[Category: Zhu, Y.]]
-
[[Category: bcl-xl]]
+
[[Category: Bcl-xl]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:21:12 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:03:01 2008''
+

Revision as of 02:21, 3 May 2008

Image:1pq0.jpg

Template:STRUCTURE 1pq0

Crystal structure of mouse Bcl-xl


Overview

After antigen-driven expansion, the majority of T cells involved in an immune response die rapidly by apoptosis dependent on the Bcl-2 related proteins, Bim and Bax or Bak. The details of how these proteins are activated and interact are still unclear. The crystal structure of mouse Bcl-x(L) bound to a long helical fragment of Bim indicates that the structure of Bim is very different from proteins with a Bcl-2-like fold and may leave the BH3 region of Bim constitutively exposed. Based on the structural homology between Bcl-x(L) and Bax, we predicted that binding of Bim to Bax would require displacement of the Bax penultimate alpha helix. Consistent with this prediction, truncation of this short helix was required for Bim/Bax interaction and led to spontaneous activation of Bax. Our results suggest a way in which both Bim and Bax/Bak might be required for activated T cell apoptosis.

About this Structure

1PQ0 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function., Liu X, Dai S, Zhu Y, Marrack P, Kappler JW, Immunity. 2003 Sep;19(3):341-52. PMID:14499110 Page seeded by OCA on Sat May 3 05:21:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pq0"
Personal tools