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6thc

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Current revision (13:02, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6thc' size='340' side='right'caption='[[6thc]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
<StructureSection load='6thc' size='340' side='right'caption='[[6thc]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6thc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_smegmatis"_trevisan_1889 "bacillus smegmatis" trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6THC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6THC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6thc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6THC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6THC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=N9N:(4-hydroxyphenyl)-[2,3,4-tris(oxidanyl)phenyl]methanone'>N9N</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.033&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">coaBC, MSMEG_3054 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1772 "Bacillus smegmatis" Trevisan 1889])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=N9N:(4-hydroxyphenyl)-[2,3,4-tris(oxidanyl)phenyl]methanone'>N9N</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6thc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6thc OCA], [http://pdbe.org/6thc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6thc RCSB], [http://www.ebi.ac.uk/pdbsum/6thc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6thc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6thc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6thc OCA], [https://pdbe.org/6thc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6thc RCSB], [https://www.ebi.ac.uk/pdbsum/6thc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6thc ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/COABC_MYCS2 COABC_MYCS2] Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.[HAMAP-Rule:MF_02225]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus smegmatis trevisan 1889]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Blaszczyk, M]]
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[[Category: Mycolicibacterium smegmatis]]
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[[Category: Blundell, T L]]
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[[Category: Blaszczyk M]]
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[[Category: Bryant, O]]
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[[Category: Blundell TL]]
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[[Category: Cory-Wright, J]]
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[[Category: Bryant O]]
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[[Category: Mendes, V]]
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[[Category: Cory-Wright J]]
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[[Category: Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase]]
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[[Category: Mendes V]]
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[[Category: Coabc]]
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[[Category: Ligase]]
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[[Category: Phosphopantothenate-cysteine ligase]]
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[[Category: Phosphopantothenoylcysteine decarboxylase]]
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[[Category: Phosphopantothenoylcysteine synthetase]]
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Current revision

Crystal structure of Mycobacterium smegmatis CoaB in complex with CTP and (4-hydroxyphenyl)(2,3,4-trihydroxyphenyl)methanone

PDB ID 6thc

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