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6tmc

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Current revision (13:05, 24 January 2024) (edit) (undo)
 
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==VIM-1_1dh-Triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-beta-lactamases==
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==VIM-2_1dh-Triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-beta-lactamases==
<StructureSection load='6tmc' size='340' side='right'caption='[[6tmc]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='6tmc' size='340' side='right'caption='[[6tmc]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6tmc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TMC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TMC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6tmc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TMC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NL5:4-[2-(phenylsulfonyl)ethyl]-5-(propan-2-yloxymethyl)-1~{H}-1,2,3-triazole'>NL5</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaVIM-2, bla vim-2, bla-VIM-2, blasVIM-2, blaVIM2, blm, VIM-2, vim-2, PAERUG_P32_London_17_VIM_2_10_11_06255 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NL5:4-[2-(phenylsulfonyl)ethyl]-5-(propan-2-yloxymethyl)-1~{H}-1,2,3-triazole'>NL5</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tmc OCA], [http://pdbe.org/6tmc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tmc RCSB], [http://www.ebi.ac.uk/pdbsum/6tmc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tmc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tmc OCA], [https://pdbe.org/6tmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tmc RCSB], [https://www.ebi.ac.uk/pdbsum/6tmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tmc ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9K2N0_PSEAI Q9K2N0_PSEAI]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Christopeit, T]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Leiros, H K.S]]
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[[Category: Christopeit T]]
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[[Category: Antibiotic]]
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[[Category: Leiros H-KS]]
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[[Category: Crystal structure]]
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[[Category: Inhibition property]]
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[[Category: Metallo-beta-lactamase inhibitor]]
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[[Category: Nh-triazole]]
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Current revision

VIM-2_1dh-Triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-beta-lactamases

PDB ID 6tmc

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