6tsz

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Current revision (13:08, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6tsz' size='340' side='right'caption='[[6tsz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='6tsz' size='340' side='right'caption='[[6tsz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6tsz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TSZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TSZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6tsz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TSZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ULK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsz OCA], [https://pdbe.org/6tsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tsz RCSB], [https://www.ebi.ac.uk/pdbsum/6tsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsz OCA], [http://pdbe.org/6tsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tsz RCSB], [http://www.ebi.ac.uk/pdbsum/6tsz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsz ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/ULK4_HUMAN ULK4_HUMAN]] Various anomalies in ULK4 gene have been reported for several cases of schizophrenia, schizophrenia plus bipolar disorder and autism. ULK4 gene has been proposed to be a rare susceptibility risk factor for a range of psychiatric diseases including schizophrenia.<ref>PMID:24284070</ref>
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[https://www.uniprot.org/uniprot/ULK4_HUMAN ULK4_HUMAN] Various anomalies in ULK4 gene have been reported for several cases of schizophrenia, schizophrenia plus bipolar disorder and autism. ULK4 gene has been proposed to be a rare susceptibility risk factor for a range of psychiatric diseases including schizophrenia.<ref>PMID:24284070</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ULK4_HUMAN ULK4_HUMAN]] May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.<ref>PMID:24284070</ref>
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[https://www.uniprot.org/uniprot/ULK4_HUMAN ULK4_HUMAN] May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.<ref>PMID:24284070</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Chatterjee D]]
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[[Category: Chatterjee, D]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M]]
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[[Category: Knapp S]]
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[[Category: Knapp, S]]
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[[Category: Mathea S]]
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[[Category: Mathea, S]]
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[[Category: Preuss F]]
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[[Category: Preuss, F]]
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[[Category: Kinase pseudokinase atp binding hypertension]]
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[[Category: Signaling protein]]
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Current revision

The ULK4 Pseudokinase Domain Bound To ATPgammaS

PDB ID 6tsz

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OCA

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