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6ttz

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Current revision (13:09, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6ttz' size='340' side='right'caption='[[6ttz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='6ttz' size='340' side='right'caption='[[6ttz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ttz]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TTZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TTZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ttz]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TTZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NWT:N-[(2S)-3-(3,5-difluorophenyl)-1-[[(3S,9S,13S,15R,19S,22S)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-1,7,17,20-tetrazatetracyclo[20.4.0.03,7.013,17]hexacosan-9-yl]amino]-1-oxopropan-2-yl]heptanamide'>NWT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v5e|3v5e]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NWT:N-[(2S)-3-(3,5-difluorophenyl)-1-[[(3S,9S,13S,15R,19S,22S)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-1,7,17,20-tetrazatetracyclo[20.4.0.03,7.013,17]hexacosan-9-yl]amino]-1-oxopropan-2-yl]heptanamide'>NWT</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">clpP, clpP_1, clpP_2, BN1321_180012, BTN44_08670, C7P97_11805, CSC83_03355, CSC87_04280, DB727_01400, E3A28_04745, E4U00_01395, EP54_12650, EQ90_03850, ERS072840_01646, ERS140147_01605, FA040_07130, FVP29_07535, HMPREF3211_00508, M1K003_1188, NCTC10654_00875, NCTC10702_01301, NCTC5664_02933, NCTC7878_03438, NCTC7988_00802, RK64_04595, SAMEA2445518_01089 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ttz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ttz OCA], [https://pdbe.org/6ttz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ttz RCSB], [https://www.ebi.ac.uk/pdbsum/6ttz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ttz ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ttz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ttz OCA], [http://pdbe.org/6ttz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ttz RCSB], [http://www.ebi.ac.uk/pdbsum/6ttz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ttz ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A077UUA2_STAAU A0A077UUA2_STAAU]] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.[HAMAP-Rule:MF_00444][RuleBase:RU000550][SAAS:SAAS00674840]
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[https://www.uniprot.org/uniprot/CLPP_STAA8 CLPP_STAA8] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Endopeptidase Clp]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Broetz-Oesterheldt, H]]
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[[Category: Staphylococcus aureus]]
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[[Category: Castro, H C]]
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[[Category: Broetz-Oesterheldt H]]
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[[Category: Famulla, K]]
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[[Category: Castro HC]]
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[[Category: Groll, M]]
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[[Category: Famulla K]]
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[[Category: Malik, I T]]
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[[Category: Groll M]]
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[[Category: Mayer, C]]
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[[Category: Malik IT]]
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[[Category: Pereira, R]]
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[[Category: Mayer C]]
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[[Category: Sass, P]]
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[[Category: Pereira R]]
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[[Category: Straetener, J]]
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[[Category: Sass P]]
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[[Category: Thomy, D]]
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[[Category: Straetener J]]
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[[Category: Vielberg, M T]]
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[[Category: Thomy D]]
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[[Category: Activator complex]]
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[[Category: Vielberg M-T]]
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[[Category: Allosteric regulation]]
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[[Category: Caseinolytic protease]]
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[[Category: Extended conformation]]
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[[Category: Hydrolase]]
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[[Category: Open state]]
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Current revision

Structure of the ClpP:ADEP4-complex from Staphylococcus aureus (open state)

PDB ID 6ttz

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