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| | <StructureSection load='6xz3' size='340' side='right'caption='[[6xz3]], [[Resolution|resolution]] 2.19Å' scene=''> | | <StructureSection load='6xz3' size='340' side='right'caption='[[6xz3]], [[Resolution|resolution]] 2.19Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6xz3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XZ3 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6xz3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XZ3 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLNRD1, MESDC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xz3 OCA], [https://pdbe.org/6xz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xz3 RCSB], [https://www.ebi.ac.uk/pdbsum/6xz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xz3 ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xz3 OCA], [https://pdbe.org/6xz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xz3 RCSB], [https://www.ebi.ac.uk/pdbsum/6xz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xz3 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[https://www.uniprot.org/uniprot/TLRN1_HUMAN TLRN1_HUMAN]] Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.<ref>PMID:22179486</ref>
| + | [https://www.uniprot.org/uniprot/TLRN1_HUMAN TLRN1_HUMAN] Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.<ref>PMID:22179486</ref> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Brown, D G]] | + | [[Category: Brown DG]] |
| - | [[Category: Cowell, A]] | + | [[Category: Cowell A]] |
| - | [[Category: Goult, B T]] | + | [[Category: Goult BT]] |
| - | [[Category: Singh, A K]] | + | [[Category: Singh AK]] |
| - | [[Category: 4-helix bundle]]
| + | |
| - | [[Category: Actin binding protein]]
| + | |
| - | [[Category: Cell adhesion]]
| + | |
| - | [[Category: Cytoskeleton]]
| + | |
| - | [[Category: Protein complex]]
| + | |
| Structural highlights
Function
TLRN1_HUMAN Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.[1]
Publication Abstract from PubMed
Talin is a mechanosensitive adapter protein that couples integrins to the cytoskeleton. Talin rod domain-containing protein 1 (TLNRD1) shares 22% homology with the talin R7R8 rod domains, and is highly conserved throughout vertebrate evolution, although little is known about its function. Here we show that TLNRD1 is an alpha-helical protein structurally homologous to talin R7R8. Like talin R7R8, TLNRD1 binds F-actin, but because it forms a novel antiparallel dimer, it also bundles F-actin. In addition, it binds the same LD motif-containing proteins, RIAM and KANK, as talin R7R8. In cells, TLNRD1 localizes to actin bundles as well as to filopodia. Increasing TLNRD1 expression enhances filopodia formation and cell migration on 2D substrates, while TLNRD1 down-regulation has the opposite effect. Together, our results suggest that TLNRD1 has retained the diverse interactions of talin R7R8, but has developed distinct functionality as an actin-bundling protein that promotes filopodia assembly.
Talin rod domain-containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation.,Cowell AR, Jacquemet G, Singh AK, Varela L, Nylund AS, Ammon YC, Brown DG, Akhmanova A, Ivaska J, Goult BT J Cell Biol. 2021 Sep 6;220(9). pii: 212472. doi: 10.1083/jcb.202005214. Epub, 2021 Jul 15. PMID:34264272[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Tatarano S, Chiyomaru T, Kawakami K, Enokida H, Yoshino H, Hidaka H, Nohata N, Yamasaki T, Gotanda T, Tachiwada T, Seki N, Nakagawa M. Novel oncogenic function of mesoderm development candidate 1 and its regulation by MiR-574-3p in bladder cancer cell lines. Int J Oncol. 2012 Apr;40(4):951-9. doi: 10.3892/ijo.2011.1294. Epub 2011 Dec 13. PMID:22179486 doi:http://dx.doi.org/10.3892/ijo.2011.1294
- ↑ Cowell AR, Jacquemet G, Singh AK, Varela L, Nylund AS, Ammon YC, Brown DG, Akhmanova A, Ivaska J, Goult BT. Talin rod domain-containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation. J Cell Biol. 2021 Sep 6;220(9). pii: 212472. doi: 10.1083/jcb.202005214. Epub, 2021 Jul 15. PMID:34264272 doi:http://dx.doi.org/10.1083/jcb.202005214
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