6y0f
From Proteopedia
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==Structure of human FAPalpha in complex with linagliptin== | ==Structure of human FAPalpha in complex with linagliptin== | ||
| - | <StructureSection load='6y0f' size='340' side='right'caption='[[6y0f]]' scene=''> | + | <StructureSection load='6y0f' size='340' side='right'caption='[[6y0f]], [[Resolution|resolution]] 2.92Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y0F FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6y0f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y0F FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y0f OCA], [https://pdbe.org/6y0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y0f RCSB], [https://www.ebi.ac.uk/pdbsum/6y0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y0f ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.924Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=356:8-[(3R)-3-AMINOPIPERIDIN-1-YL]-7-BUT-2-YN-1-YL-3-METHYL-1-[(4-METHYLQUINAZOLIN-2-YL)METHYL]-3,7-DIHYDRO-1H-PURINE-2,6-DIONE'>356</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y0f OCA], [https://pdbe.org/6y0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y0f RCSB], [https://www.ebi.ac.uk/pdbsum/6y0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y0f ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SEPR_HUMAN SEPR_HUMAN] In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.<ref>PMID:16651416</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Prolyl Endopeptidase|Prolyl Endopeptidase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Nar H]] | [[Category: Nar H]] | ||
[[Category: Schnapp G]] | [[Category: Schnapp G]] | ||
[[Category: Schreiner P]] | [[Category: Schreiner P]] | ||
Revision as of 13:16, 24 January 2024
Structure of human FAPalpha in complex with linagliptin
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