1pqv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1pqv.gif|left|200px]]
[[Image:1pqv.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1pqv |SIZE=350|CAPTION= <scene name='initialview01'>1pqv</scene>, resolution 3.80&Aring;
+
The line below this paragraph, containing "STRUCTURE_1pqv", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1pqv| PDB=1pqv | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pqv OCA], [http://www.ebi.ac.uk/pdbsum/1pqv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pqv RCSB]</span>
+
-
}}
+
'''RNA polymerase II-TFIIS complex'''
'''RNA polymerase II-TFIIS complex'''
Line 29: Line 26:
[[Category: Cramer, P.]]
[[Category: Cramer, P.]]
[[Category: Kettenberger, H.]]
[[Category: Kettenberger, H.]]
-
[[Category: backtracking]]
+
[[Category: Backtracking]]
-
[[Category: gene expression]]
+
[[Category: Gene expression]]
-
[[Category: mrna cleavage]]
+
[[Category: Mrna cleavage]]
-
[[Category: multiprotein complex]]
+
[[Category: Multiprotein complex]]
-
[[Category: proofreading]]
+
[[Category: Proofreading]]
-
[[Category: protein soaking]]
+
[[Category: Protein soaking]]
-
[[Category: transcription]]
+
[[Category: Transcription]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:23:11 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:03:19 2008''
+

Revision as of 02:23, 3 May 2008

Image:1pqv.gif

Template:STRUCTURE 1pqv

RNA polymerase II-TFIIS complex


Overview

The transcription elongation factor TFIIS induces mRNA cleavage by enhancing the intrinsic nuclease activity of RNA polymerase (Pol) II. We have diffused TFIIS into Pol II crystals and derived a model of the Pol II-TFIIS complex from X-ray diffraction data to 3.8 A resolution. TFIIS extends from the polymerase surface via a pore to the internal active site, spanning a distance of 100 A. Two essential and invariant acidic residues in a TFIIS loop complement the Pol II active site and could position a metal ion and a water molecule for hydrolytic RNA cleavage. TFIIS also induces extensive structural changes in Pol II that would realign nucleic acids in the active center. Our results support the idea that Pol II contains a single tunable active site for RNA polymerization and cleavage, in contrast to DNA polymerases with two separate active sites for DNA polymerization and cleavage.

About this Structure

1PQV is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage., Kettenberger H, Armache KJ, Cramer P, Cell. 2003 Aug 8;114(3):347-57. PMID:12914699 Page seeded by OCA on Sat May 3 05:23:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pqv"
Personal tools