6y8m

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Current revision (13:21, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6y8m' size='340' side='right'caption='[[6y8m]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='6y8m' size='340' side='right'caption='[[6y8m]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6y8m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Y8M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6y8m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y8M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SX2:4-[(5-BROMOPYRIDIN-2-YL)AMINO]-4-OXOBUTANOIC+ACID'>SX2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6y8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y8m OCA], [http://pdbe.org/6y8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y8m RCSB], [http://www.ebi.ac.uk/pdbsum/6y8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y8m ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SX2:4-[(5-BROMOPYRIDIN-2-YL)AMINO]-4-OXOBUTANOIC+ACID'>SX2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y8m OCA], [https://pdbe.org/6y8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y8m RCSB], [https://www.ebi.ac.uk/pdbsum/6y8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y8m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN]] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
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[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
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==See Also==
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*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Nichols, C E]]
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[[Category: De Nicola GF]]
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[[Category: Nicola, G F.De]]
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[[Category: Nichols CE]]
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[[Category: Fbdd]]
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[[Category: Fragment based drug design]]
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[[Category: Il1b]]
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[[Category: Signaling protein]]
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[[Category: Xchem]]
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Current revision

Fragment bikinin bound to Interleukin 1 beta

PDB ID 6y8m

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