6y9m

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<StructureSection load='6y9m' size='340' side='right'caption='[[6y9m]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
<StructureSection load='6y9m' size='340' side='right'caption='[[6y9m]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6y9m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Tswv Tswv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y9M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6y9m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Tomato_spotted_wilt_virus_(strain_Brazilian_BR-01) Tomato spotted wilt virus (strain Brazilian BR-01)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y9M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gn, Gc ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36413 TSWV])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y9m OCA], [https://pdbe.org/6y9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y9m RCSB], [https://www.ebi.ac.uk/pdbsum/6y9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y9m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y9m OCA], [https://pdbe.org/6y9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y9m RCSB], [https://www.ebi.ac.uk/pdbsum/6y9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y9m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/A0A3G1GK10_TSWV A0A3G1GK10_TSWV]] Together with Glycoprotein C are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion.[ARBA:ARBA00002373] Together with Glycoprotein N are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion.[ARBA:ARBA00004076]
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[https://www.uniprot.org/uniprot/GP_TSWV1 GP_TSWV1] Forms the spikes present at the surface of the virion together with Glycoprotein C. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity). Plays a role in virus binding and/or entry into the vector midgut (PubMed:31413126).[UniProtKB:P08668]<ref>PMID:31413126</ref> Forms the spikes present at the surface of the virion together with Glycoprotein N. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity). Probable class II fusion protein (PubMed:33672327).[UniProtKB:P08668]<ref>PMID:33672327</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tospoviridae is a family of enveloped RNA plant viruses that infect many field crops, inflicting a heavy global economic burden. These tripartite, single-stranded, negative-sense RNA viruses are transmitted from plant to plant by thrips as the insect vector. The medium (M) segment of the viral genome encodes two envelope glycoproteins, GN and GC, which together form the envelope spikes. GC is considered the virus fusogen, while the accompanying GN protein serves as an attachment protein that binds to a yet unknown receptor, mediating the virus acquisition by the thrips carrier. Here we present the crystal structure of glycoprotein N (GN) from the tomato spotted wilt virus (TSWV), a representative member of the Tospoviridae family. The structure suggests that GN is organized as dimers on TSWV's outer shell. Our structural data also suggest that this dimerization is required for maintaining GN structural integrity. Although the structure of the TSWV GN is different from other bunyavirus GN proteins, they all share similar domain connectivity that resembles glycoproteins from unrelated animal-infecting viruses, suggesting a common ancestor for these accompanying proteins.
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Crystal structure of tomato spotted wilt virus GN reveals a dimer complex formation and evolutionary link to animal-infecting viruses.,Bahat Y, Alter J, Dessau M Proc Natl Acad Sci U S A. 2020 Oct 5. pii: 2004657117. doi:, 10.1073/pnas.2004657117. PMID:33020295<ref>PMID:33020295</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6y9m" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Tswv]]
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[[Category: Bahat Y]]
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[[Category: Bahat, Y]]
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[[Category: Dessau M]]
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[[Category: Dessau, M]]
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[[Category: Attachment]]
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[[Category: Envelope protein]]
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[[Category: Receptor binding]]
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[[Category: Viral assembly]]
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[[Category: Viral entry]]
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[[Category: Viral protein]]
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Revision as of 13:22, 24 January 2024

Crystal structure of TSWV glycoprotein N ectodomain (sGn)

PDB ID 6y9m

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