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6yb9

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Current revision (13:23, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6yb9' size='340' side='right'caption='[[6yb9]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
<StructureSection load='6yb9' size='340' side='right'caption='[[6yb9]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6yb9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YB9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YB9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6yb9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YB9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OK8:(2~{S})-2-[[5-azanyl-1-[(2~{R},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]car+bonylamino]butanedioic+acid'>OK8</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.406&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6yb8|6yb8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OK8:(2~{S})-2-[[5-azanyl-1-[(2~{R},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]car+bonylamino]butanedioic+acid'>OK8</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PAICS, ADE2, AIRC, PAIS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yb9 OCA], [https://pdbe.org/6yb9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yb9 RCSB], [https://www.ebi.ac.uk/pdbsum/6yb9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yb9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yb9 OCA], [http://pdbe.org/6yb9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yb9 RCSB], [http://www.ebi.ac.uk/pdbsum/6yb9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yb9 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PUR6_HUMAN PUR6_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gottmann, M]]
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[[Category: Gottmann M]]
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[[Category: Helleday, T]]
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[[Category: Helleday T]]
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[[Category: Homan, E]]
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[[Category: Homan E]]
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[[Category: Jemth, A S]]
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[[Category: Jemth AS]]
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[[Category: Skerlova, J]]
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[[Category: Skerlova J]]
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[[Category: Stenmark, P]]
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[[Category: Stenmark P]]
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[[Category: Unterlass, J]]
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[[Category: Unterlass J]]
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[[Category: Biosynthetic protein]]
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[[Category: Cancer target]]
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[[Category: De novo purine biosynthesis]]
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[[Category: Nucleotide metabolism]]
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Current revision

Human octameric PAICS in complex with SAICAR, AMP-PNP, and magnesium

PDB ID 6yb9

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