6yic

==14-3-3 sigma in complex with SMAD4 pS403 peptide==

<StructureSection load='6yic' size='340' side='right'caption='[[6yic]], [[Resolution|resolution]] 1.60&Aring;' scene=''>

<table><tr><td colspan='2'>[[6yic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YIC FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yic OCA], [https://pdbe.org/6yic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yic RCSB], [https://www.ebi.ac.uk/pdbsum/6yic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yic ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

[[Category: Homo sapiens]]

[[Category: Graf S]]

[[Category: Kiehstaller S]]