6ym3

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Current revision (13:30, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6ym3' size='340' side='right'caption='[[6ym3]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='6ym3' size='340' side='right'caption='[[6ym3]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ym3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YM3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ym3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YM3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OYZ:(2~{R})-2-[[3-cyano-2-[4-(2-ethoxyphenyl)phenyl]-5,8-dihydro-1,7-naphthyridin-4-yl]amino]propanoic+acid'>OYZ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OYZ:(2~{R})-2-[[3-cyano-2-[4-(2-ethoxyphenyl)phenyl]-5,8-dihydro-1,7-naphthyridin-4-yl]amino]propanoic+acid'>OYZ</scene>, <scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIP4K2A, PIP5K2, PIP5K2A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/1-phosphatidylinositol-5-phosphate_4-kinase 1-phosphatidylinositol-5-phosphate 4-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.149 2.7.1.149] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ym3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ym3 OCA], [https://pdbe.org/6ym3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ym3 RCSB], [https://www.ebi.ac.uk/pdbsum/6ym3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ym3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ym3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ym3 OCA], [https://pdbe.org/6ym3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ym3 RCSB], [https://www.ebi.ac.uk/pdbsum/6ym3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ym3 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/PI42A_HUMAN PI42A_HUMAN]] Precursor B-cell acute lymphoblastic leukemia.
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[https://www.uniprot.org/uniprot/PI42A_HUMAN PI42A_HUMAN] Precursor B-cell acute lymphoblastic leukemia.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PI42A_HUMAN PI42A_HUMAN]] Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.<ref>PMID:18364242</ref>
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[https://www.uniprot.org/uniprot/PI42A_HUMAN PI42A_HUMAN] Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.<ref>PMID:18364242</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 1-phosphatidylinositol-5-phosphate 4-kinase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bauser, M]]
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[[Category: Bauser M]]
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[[Category: Braeuer, N]]
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[[Category: Braeuer N]]
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[[Category: Christ, C]]
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[[Category: Christ C]]
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[[Category: Haegebarth, A]]
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[[Category: Haegebarth A]]
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[[Category: Holton, S J]]
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[[Category: Holton SJ]]
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[[Category: Irlbacher, H]]
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[[Category: Irlbacher H]]
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[[Category: Laak, T ter]]
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[[Category: Lechner C]]
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[[Category: Lechner, C]]
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[[Category: Lemos C]]
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[[Category: Lemos, C]]
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[[Category: Lesche R]]
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[[Category: Lesche, R]]
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[[Category: Lienau P]]
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[[Category: Lienau, P]]
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[[Category: Meier R]]
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[[Category: Meier, R]]
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[[Category: Mumberg D]]
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[[Category: Mumberg, D]]
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[[Category: Nicke B]]
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[[Category: Nicke, B]]
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[[Category: Puetter V]]
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[[Category: Nussbaum, F von]]
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[[Category: Weiske J]]
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[[Category: Puetter, V]]
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[[Category: Wortmann L]]
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[[Category: Weiske, J]]
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[[Category: Ter Laak T]]
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[[Category: Wortmann, L]]
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[[Category: Von Nussbaum F]]
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[[Category: Pip4k2a]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Compound 1 with PIP4K2A

PDB ID 6ym3

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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