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6z1t

From Proteopedia

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Current revision (13:40, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6z1t' size='340' side='right'caption='[[6z1t]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
<StructureSection load='6z1t' size='340' side='right'caption='[[6z1t]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6z1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Z1T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6z1t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z1T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q55:4S/3694'>Q55</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6z1q|6z1q]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q55:4S/3694'>Q55</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAP3K14, NIK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1t OCA], [https://pdbe.org/6z1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z1t RCSB], [https://www.ebi.ac.uk/pdbsum/6z1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1t ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6z1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1t OCA], [http://pdbe.org/6z1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6z1t RCSB], [http://www.ebi.ac.uk/pdbsum/6z1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1t ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/M3K14_HUMAN M3K14_HUMAN]] Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.<ref>PMID:15084608</ref>
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[https://www.uniprot.org/uniprot/M3K14_HUMAN M3K14_HUMAN] Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.<ref>PMID:15084608</ref>
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==See Also==
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*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mitogen-activated protein kinase kinase kinase]]
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[[Category: Attar R]]
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[[Category: Attar, R]]
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[[Category: Hynd G]]
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[[Category: Hynd, G]]
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[[Category: Jacoby E]]
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[[Category: Jacoby, E]]
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[[Category: Meerpoel L]]
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[[Category: Meerpoel, L]]
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[[Category: Querolle O]]
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[[Category: Querolle, O]]
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[[Category: Stansfield I]]
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[[Category: Stansfield, I]]
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[[Category: Versele M]]
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[[Category: Versele, M]]
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[[Category: Van Vlijmen H]]
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[[Category: Vlijmen, H van]]
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[[Category: Free energy perturbation]]
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[[Category: Jnj64290694]]
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[[Category: Lead optimization]]
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[[Category: Multiple myeloma]]
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[[Category: Nik]]
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[[Category: Transferase]]
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Current revision

MAP3K14 (NIK) in complex with 4S/3694

PDB ID 6z1t

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