6z2c
From Proteopedia
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==Engineered lipocalin C3A5 in complex with a transition state analog== | ==Engineered lipocalin C3A5 in complex with a transition state analog== | ||
| - | <StructureSection load='6z2c' size='340' side='right'caption='[[6z2c]]' scene=''> | + | <StructureSection load='6z2c' size='340' side='right'caption='[[6z2c]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z2C FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6z2c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z2C FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z2c OCA], [https://pdbe.org/6z2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z2c RCSB], [https://www.ebi.ac.uk/pdbsum/6z2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z2c ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q5E:1,7,8,9,10,10-hexachloro-4-carboxypentyl-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione'>Q5E</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z2c OCA], [https://pdbe.org/6z2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z2c RCSB], [https://www.ebi.ac.uk/pdbsum/6z2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z2c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NGAL_HUMAN NGAL_HUMAN] Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.<ref>PMID:12453413</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Neutrophil gelatinase-associated lipocalin|Neutrophil gelatinase-associated lipocalin]] | ||
| + | *[[Siderocalin 3D structures|Siderocalin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Eichinger A]] | [[Category: Eichinger A]] | ||
[[Category: Skerra A]] | [[Category: Skerra A]] | ||
Revision as of 13:40, 24 January 2024
Engineered lipocalin C3A5 in complex with a transition state analog
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