1prq
From Proteopedia
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'''ACANTHAMOEBA CASTELLANII PROFILIN IA''' | '''ACANTHAMOEBA CASTELLANII PROFILIN IA''' | ||
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[[Category: Pollard, T D.]] | [[Category: Pollard, T D.]] | ||
[[Category: Way, M.]] | [[Category: Way, M.]] | ||
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Revision as of 02:24, 3 May 2008
ACANTHAMOEBA CASTELLANII PROFILIN IA
Overview
Profilin-I from Acanthamoeba castellanii is a 13-kDa protein that binds actin and poly-l-proline. The native protein has been crystallized in two different but closely related forms. The second form proved more amenable to three-dimensional structural determination using heavy-atom isomorphous methods to obtain crystallographic phase information. We used the second crystal structure as a test molecule in the molecular replacement procedure to determine the structure of the first crystal form of profilin-I. More residues participate in crystal lattice contacts in the first crystal form than in the second. The two crystal forms differ significantly in the C-terminal helix that interacts with actin and in the loop preceding this helix. Coordinates of some main chain atoms here differ by about 1.0 A, and side chain atoms differ by more than 2.0 A.
About this Structure
1PRQ is a Single protein structure of sequence from Acanthamoeba castellanii. Full crystallographic information is available from OCA.
Reference
Crystal packing induces a conformational change in profilin-I from Acanthamoeba castellanii., Liu S, Fedorov AA, Pollard TD, Lattman EE, Almo SC, Magnus KA, J Struct Biol. 1998 Sep;123(1):22-9. PMID:9774541 Page seeded by OCA on Sat May 3 05:24:36 2008
