1rj8

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Revision as of 16:57, 12 November 2007

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spinqualitylabelsall models 1rj8, resolution 2.23Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

The crystal structure of TNF family member EDA-A2

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

EDA is a tumor necrosis factor family member involved in ectodermal, development. Splice variants EDA-A1 and EDA-A2 differ only by the presence, of Glu 308 and Val 309 in the expected receptor binding region of EDA-A1, but not EDA-A2. This two amino acid difference functions as a switch, controlling receptor specificity. EDA-A1 binds only to EDAR, while EDA-A2, is specific for XEDAR. In order to understand the structural basis of this, switch, we determined the X-ray crystal structures of the TNF domain of, both EDA-A1 and EDA-A2 at 2.3 A and 2.2 A, respectively. While the, backbone conformation around the splice difference is similar in both, isoforms, the conformation of the following loop, the surface charge, and, the shape of the expected receptor binding site differ significantly.

Disease

Known diseases associated with this structure: Ectodermal dysplasia-1, anhidrotic OMIM:[300451], Hypodontia, X-linked OMIM:[300451]

About this Structure

1RJ8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity., Hymowitz SG, Compaan DM, Yan M, Wallweber HJ, Dixit VM, Starovasnik MA, de Vos AM, Structure. 2003 Dec;11(12):1513-20. PMID:14656435

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