1prw

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[[Image:1prw.jpg|left|200px]]
[[Image:1prw.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1prw |SIZE=350|CAPTION= <scene name='initialview01'>1prw</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1prw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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{{STRUCTURE_1prw| PDB=1prw | SCENE= }}
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|RELATEDENTRY=[[1cln|1CLN]], [[1cdl|1CDL]], [[1cdm|1CDM]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1prw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1prw OCA], [http://www.ebi.ac.uk/pdbsum/1prw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1prw RCSB]</span>
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}}
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'''Crystal structure of bovine brain Ca++ calmodulin in a compact form'''
'''Crystal structure of bovine brain Ca++ calmodulin in a compact form'''
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[[Category: Fallon, J L.]]
[[Category: Fallon, J L.]]
[[Category: Quiocho, F A.]]
[[Category: Quiocho, F A.]]
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[[Category: calcium-binding protein]]
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[[Category: Calcium-binding protein]]
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[[Category: ef hand]]
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[[Category: Ef hand]]
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[[Category: kinase activator]]
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[[Category: Kinase activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:25:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:03:44 2008''
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Revision as of 02:25, 3 May 2008

Image:1prw.jpg

Template:STRUCTURE 1prw

Crystal structure of bovine brain Ca++ calmodulin in a compact form


Overview

Calmodulin has been a subject of intense scrutiny since its discovery because of its unusual properties in regulating the functions of about 100 diverse target enzymes and structural proteins. The original and to date only crystal conformation of native eukaryotic Ca(2+)-calmodulin (Ca(2+)-CaM) is a very extended molecule with two widely separated globular domains linked by an exposed long helix. Here we report the 1.7 A X-ray structure of a new native Ca(2+)-CaM that is in a compact ellipsoidal conformation and shows a sharp bend in the linker helix and a more contracted N-terminal domain. This conformation may offer advantages for recognition of kinase-type calmodulin targets or small organic molecule drugs.

About this Structure

1PRW is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

A closed compact structure of native Ca(2+)-calmodulin., Fallon JL, Quiocho FA, Structure. 2003 Oct;11(10):1303-7. PMID:14527397 Page seeded by OCA on Sat May 3 05:25:00 2008

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