1ps1

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[[Image:1ps1.jpg|left|200px]]
[[Image:1ps1.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1ps1 |SIZE=350|CAPTION= <scene name='initialview01'>1ps1</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1ps1", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AR1:Aspartate-Rich+Region,+Monomer+A'>AR1</scene> and <scene name='pdbsite=AR2:Aspartate-Rich+Region,+Monomer+B'>AR2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PBM:TRIMETHYL+LEAD+ION'>PBM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pentalenene_synthase Pentalenene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.7 4.2.3.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1ps1| PDB=1ps1 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ps1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ps1 OCA], [http://www.ebi.ac.uk/pdbsum/1ps1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ps1 RCSB]</span>
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}}
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'''PENTALENENE SYNTHASE'''
'''PENTALENENE SYNTHASE'''
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[[Category: Christianson, D W.]]
[[Category: Christianson, D W.]]
[[Category: Lesburg, C A.]]
[[Category: Lesburg, C A.]]
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[[Category: antibiotic biosynthesis]]
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[[Category: Antibiotic biosynthesis]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: sesquiterpene cyclase]]
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[[Category: Sesquiterpene cyclase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:25:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:03:46 2008''
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Revision as of 02:25, 3 May 2008

Image:1ps1.jpg

Template:STRUCTURE 1ps1

PENTALENENE SYNTHASE


Overview

The crystal structure of pentalenene synthase at 2.6 angstrom resolution reveals critical active site features responsible for the cyclization of farnesyl diphosphate into the tricyclic hydrocarbon pentalenene. Metal-triggered substrate ionization initiates catalysis, and the alpha-barrel active site serves as a template to channel and stabilize the conformations of reactive carbocation intermediates through a complex cyclization cascade. The core active site structure of the enzyme may be preserved among the greater family of terpenoid synthases, possibly implying divergence from a common ancestral synthase to satisfy biological requirements for increasingly diverse natural products.

About this Structure

1PS1 is a Single protein structure of sequence from Streptomyces sp.. Full crystallographic information is available from OCA.

Reference

Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology., Lesburg CA, Zhai G, Cane DE, Christianson DW, Science. 1997 Sep 19;277(5333):1820-4. PMID:9295272 Page seeded by OCA on Sat May 3 05:25:15 2008

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OCA

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