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3j6u

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<SX load='3j6u' size='340' side='right' viewer='molstar' caption='[[3j6u]], [[Resolution|resolution]] 9.00&Aring;' scene=''>
<SX load='3j6u' size='340' side='right' viewer='molstar' caption='[[3j6u]], [[Resolution|resolution]] 9.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3j6u]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J6U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3j6u]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J6U FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3j6s|3j6s]], [[3j6t|3j6t]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6u OCA], [https://pdbe.org/3j6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j6u RCSB], [https://www.ebi.ac.uk/pdbsum/3j6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6u OCA], [https://pdbe.org/3j6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j6u RCSB], [https://www.ebi.ac.uk/pdbsum/3j6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/Q6DLV0_9FLAV Q6DLV0_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774]
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[https://www.uniprot.org/uniprot/A9LID6_9FLAV A9LID6_9FLAV]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Dengue virus 3]]
[[Category: Dengue virus 3]]
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Alwis, R de]]
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[[Category: Crowe Jr JE]]
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[[Category: Crowe, J E]]
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[[Category: Fibriansah G]]
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[[Category: Fibriansah, G]]
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[[Category: Kostyuchenko VA]]
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[[Category: Kostyuchenko, V A]]
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[[Category: Kukkaro P]]
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[[Category: Kukkaro, P]]
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[[Category: Lok S-M]]
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[[Category: Lok, S M]]
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[[Category: Ng T-S]]
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[[Category: Ng, T S]]
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[[Category: Smith SA]]
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[[Category: Silva, A M.de]]
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[[Category: Tan JL]]
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[[Category: Smith, S A]]
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[[Category: De Alwis R]]
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[[Category: Tan, J L]]
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[[Category: De Silva AM]]
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[[Category: Dengue virus]]
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[[Category: Human antibody]]
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[[Category: Neutralization]]
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[[Category: Virus-immune system complex]]
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Revision as of 14:16, 24 January 2024

Cryo-EM structure of Dengue virus serotype 3 in complex with human antibody 5J7 Fab

3j6u, resolution 9.00Å

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