1rjt
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(New page: 200px<br /> <applet load="1rjt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rjt" /> '''NMR Structure of CXC Chemokine CXCL11/ITAC'...)
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Revision as of 16:58, 12 November 2007
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NMR Structure of CXC Chemokine CXCL11/ITAC
Overview
CXCL11 (ITAC) is one of three chemokines known to bind the receptor CXCR3, the two others being CXCL9 (Mig) and CXCL10 (IP-10). CXCL11 differs from, the other CXCR3 ligands in both the strength and the particularities of, its receptor interactions: It has a higher affinity, is a stronger, agonist, and behaves differently when critical N-terminal residues are, deleted. The structure of CXCL11 was determined using solution NMR to, allow comparison with that of CXCL10 and help elucidate the source of the, differences. CXCL11 takes on the canonical chemokine fold but exhibits, greater conformational flexibility than has been observed for related, chemokines under the same sample conditions. Unlike related chemokines, such as IP-10 and IL-8, ITAC does not appear to form dimers at millimolar, concentrations. The origin for this behavior can be found in the solution, structure, which indicates a beta-bulge in beta-strand 1 that distorts the, dimerization interface used by other CXC chemokines.
About this Structure
1RJT is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
NMR structure of CXCR3 binding chemokine CXCL11 (ITAC)., Booth V, Clark-Lewis I, Sykes BD, Protein Sci. 2004 Aug;13(8):2022-8. PMID:15273303
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