1psj

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[[Image:1psj.gif|left|200px]]
[[Image:1psj.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1psj |SIZE=350|CAPTION= <scene name='initialview01'>1psj</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1psj", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_1psj| PDB=1psj | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [http://www.ebi.ac.uk/pdbsum/1psj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB]</span>
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'''ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS'''
'''ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS'''
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Crystal structure of an acidic phospholipase A2 from the venom of Agkistrodon halys pallas at 2.0 A resolution., Wang XQ, Yang J, Gui LL, Lin ZJ, Chen YC, Zhou YC, J Mol Biol. 1996 Feb 9;255(5):669-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8636969 8636969]
Crystal structure of an acidic phospholipase A2 from the venom of Agkistrodon halys pallas at 2.0 A resolution., Wang XQ, Yang J, Gui LL, Lin ZJ, Chen YC, Zhou YC, J Mol Biol. 1996 Feb 9;255(5):669-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8636969 8636969]
[[Category: Gloydius halys]]
[[Category: Gloydius halys]]
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[[Category: Phospholipase A(2)]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Lin, Z J.]]
[[Category: Lin, Z J.]]
[[Category: Wang, X Q.]]
[[Category: Wang, X Q.]]
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[[Category: calcium]]
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[[Category: Calcium]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: lipid degradation]]
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[[Category: Lipid degradation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:26:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:04:02 2008''
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Revision as of 02:26, 3 May 2008

Image:1psj.gif

Template:STRUCTURE 1psj

ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS


Overview

The crystal structure of acidic phospholipase A2 from the venom of Agkistrodon halys pallas has been determined by molecular replacement at 2.0 A resolution to a crystallographic R-factor of 0.157. The overall structure of the molecule is very similar to those of other phospholipase A2 species of known structure. The catalytic site, the hydrophobic channel and the N-terminal region show greatest structural conservation. The Ca(2+)-binding region has a conformation that resembles closely that of bovine PLA2 rather than Crotalus atrox PLA2. Compared with other PLA2 species, the conformation of the C-terminal ridge shows significant difference due to the insertion of two residues. A unique aromatic patch appears on one face of the molecules, surrounded by two acidic residues, the relevant features of this structure and their possible biological implications are discussed.

About this Structure

1PSJ is a Single protein structure of sequence from Gloydius halys. Full crystallographic information is available from OCA.

Reference

Crystal structure of an acidic phospholipase A2 from the venom of Agkistrodon halys pallas at 2.0 A resolution., Wang XQ, Yang J, Gui LL, Lin ZJ, Chen YC, Zhou YC, J Mol Biol. 1996 Feb 9;255(5):669-76. PMID:8636969 Page seeded by OCA on Sat May 3 05:26:19 2008

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