1psz
From Proteopedia
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'''PNEUMOCOCCAL SURFACE ANTIGEN PSAA''' | '''PNEUMOCOCCAL SURFACE ANTIGEN PSAA''' | ||
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[[Category: Paton, J C.]] | [[Category: Paton, J C.]] | ||
[[Category: Pilling, P A.]] | [[Category: Pilling, P A.]] | ||
| - | [[Category: | + | [[Category: Abc-type binding protein]] |
| - | [[Category: | + | [[Category: Metal-binding protein]] |
| - | [[Category: | + | [[Category: Pneumococcal surface antigen]] |
| - | [[Category: | + | [[Category: Psaa]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:27:08 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 02:27, 3 May 2008
PNEUMOCOCCAL SURFACE ANTIGEN PSAA
Overview
Background:. The surface protein PsaA of the pathogenic bacterium Streptococcus pneumoniae plays an essential role in its virulence. PsaA is a putative ATP-binding cassette-type (ABC-type) binding protein involved in the uptake of Mn2+ and possibly Zn2+ and is considered to be both a potential drug target and and a candidate vaccine component. Results:. The structure of PsaA has been determined to 2.0 A resolution using X-ray crystallography and is the first structure obtained for an ABC-type binding protein from a Gram-positive organism. The protein consists of two (beta/alpha)4 domains linked together by a single helix. A metal-binding site is formed in the domain interface by the sidechains of His67, His139, Glu205 and Asp280 and is occupied in the structure. Conclusions:. The structural topology of PsaA is fundamentally different from that of other ABC-type binding proteins determined thus far in that PsaA lacks the characteristic 'hinge peptides' involved in conformational change upon solute uptake and release. In our structure, the metal-binding site is probably occupied by Zn2+. The site seems to be well conserved amongst related receptors from both Gram-positive and Gram-negative bacteria.
About this Structure
1PSZ is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.
Reference
The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein., Lawrence MC, Pilling PA, Epa VC, Berry AM, Ogunniyi AD, Paton JC, Structure. 1998 Dec 15;6(12):1553-61. PMID:9862808 Page seeded by OCA on Sat May 3 05:27:08 2008
