1rkb
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1rkb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rkb, resolution 2.00Å" /> '''The structure of ad...)
Next diff →
Revision as of 16:58, 12 November 2007
|
The structure of adrenal gland protein AD-004
Overview
Adenylate kinases (AKs) play important roles in nucleotide metabolism in, all organisms and in cellular energetics by means of phosphotransfer, networks in eukaryotes. The crystal structure of a human AK named AK6 was, determined by in-house sulfur single-wavelength anomalous dispersion, phasing methods and refined to 2.0-A resolution with a free R factor of, 21.8%. Sequence analyses revealed that human AK6 belongs to a distinct, subfamily of AKs present in all eukaryotic organisms sequenced so far., Enzymatic assays show that human AK6 has properties similar with other, AKs, particularly with AK5. Fluorescence microscopy showed that human AK6, is localized predominantly to the nucleus of HeLa cells. The, identification of a nuclear-localized AK sheds light on nucleotide, metabolism in the nucleus and the energetic communication between, mitochondria and nucleus by means of phosphotransfer networks.
About this Structure
1RKB is a Single protein structure of sequence from Homo sapiens with SO4 and LI as ligands. Full crystallographic information is available from OCA.
Reference
The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus., Ren H, Wang L, Bennett M, Liang Y, Zheng X, Lu F, Li L, Nan J, Luo M, Eriksson S, Zhang C, Su XD, Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):303-8. Epub 2005 Jan 3. PMID:15630091
Page seeded by OCA on Mon Nov 12 19:04:55 2007
