1pto

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1pto.jpg|left|200px]]
[[Image:1pto.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1pto |SIZE=350|CAPTION= <scene name='initialview01'>1pto</scene>, resolution 3.5&Aring;
+
The line below this paragraph, containing "STRUCTURE_1pto", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1pto| PDB=1pto | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pto OCA], [http://www.ebi.ac.uk/pdbsum/1pto PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pto RCSB]</span>
+
-
}}
+
'''THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING'''
'''THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING'''
Line 27: Line 24:
[[Category: Read, R J.]]
[[Category: Read, R J.]]
[[Category: Stein, P E.]]
[[Category: Stein, P E.]]
-
[[Category: toxin]]
+
[[Category: Toxin]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:28:17 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:04:25 2008''
+

Revision as of 02:28, 3 May 2008

Image:1pto.jpg

Template:STRUCTURE 1pto

THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING


Overview

Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis which is important the pathogenesis of whooping cough and the generation of a protective immune response. The diverse biological activities of the toxin depend on its ability to recognize carbohydrate-containing receptors on a wide variety of eukaryotic cells. We present here the crystal structure of pertussis toxin complexed with a soluble oligosaccharide from transferrin. Binding sites for the terminal sialic acid-galactose moiety are revealed on both subunits S2 and S3 of the B-oligomer. Identification of amino acid residues involved in receptor binding will improve the design of genetically inactivated toxins for use in new acellular whooping cough vaccines.

About this Structure

1PTO is a Protein complex structure of sequences from Bordetella pertussis. Full crystallographic information is available from OCA.

Reference

Structure of a pertussis toxin-sugar complex as a model for receptor binding., Stein PE, Boodhoo A, Armstrong GD, Heerze LD, Cockle SA, Klein MH, Read RJ, Nat Struct Biol. 1994 Sep;1(9):591-6. PMID:7634099 Page seeded by OCA on Sat May 3 05:28:17 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pto"
Personal tools