8c8d
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 44).== | |
| - | + | <StructureSection load='8c8d' size='340' side='right'caption='[[8c8d]], [[Resolution|resolution]] 1.46Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8c8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C8D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U2C:(2~{R})-3-[6-chloranyl-2-(furan-2-ylmethylamino)quinazolin-4-yl]-2-methyl-~{N}-oxidanyl-propanamide'>U2C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c8d OCA], [https://pdbe.org/8c8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c8d RCSB], [https://www.ebi.ac.uk/pdbsum/8c8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c8d ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/DCR1A_HUMAN DCR1A_HUMAN] May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.<ref>PMID:15542852</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Schofield | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Baddock HT]] | ||
| + | [[Category: Bielinski M]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Gileadi O]] | ||
| + | [[Category: McHugh PJ]] | ||
| + | [[Category: Newman JA]] | ||
| + | [[Category: Schofield CJ]] | ||
| + | [[Category: Yosaatmadja Y]] | ||
| + | [[Category: Von Delft F]] | ||
Revision as of 11:40, 1 February 2024
Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 44).
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