8c9h

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Current revision (11:40, 1 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8c9h is ON HOLD until Paper Publication
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==AQP7_inhibitor==
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<StructureSection load='8c9h' size='340' side='right'caption='[[8c9h]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8c9h]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C9H FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T60:ethyl+4-[(4-pyrazol-1-ylphenyl)methylcarbamoylamino]benzoate'>T60</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c9h OCA], [https://pdbe.org/8c9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c9h RCSB], [https://www.ebi.ac.uk/pdbsum/8c9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c9h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gourdon P]]
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[[Category: Huang P]]
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[[Category: Lindkvist-Petersson K]]
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[[Category: Venskutonyte R]]

Current revision

AQP7_inhibitor

PDB ID 8c9h

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