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8hw9

From Proteopedia

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Current revision (11:42, 1 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8hw9 is ON HOLD until Paper Publication
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==Solution structure of ubiquitin-like domain (UBL) of human ZFAND1==
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<StructureSection load='8hw9' size='340' side='right'caption='[[8hw9]]' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8hw9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HW9 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hw9 OCA], [https://pdbe.org/8hw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hw9 RCSB], [https://www.ebi.ac.uk/pdbsum/8hw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hw9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZFAN1_HUMAN ZFAN1_HUMAN] Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830).<ref>PMID:29804830</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chang CF]]
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[[Category: Fan PJ]]
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[[Category: Hsu STD]]
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[[Category: Ko KT]]
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[[Category: Lai CH]]
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[[Category: Yu TA]]

Current revision

Solution structure of ubiquitin-like domain (UBL) of human ZFAND1

PDB ID 8hw9

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