8v04

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'''Unreleased structure'''
 
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The entry 8v04 is ON HOLD
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==High resolution TMPRSS2 structure following acylation by nafamostat==
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<StructureSection load='8v04' size='340' side='right'caption='[[8v04]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
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Authors: Fraser, B.J., Dong, A., Kutera, M., Seitova, A., Li, Y., Hutchinson, A., Edwards, A., Benard, F., Levon, H., Arrowsmith, C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8v04]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V04 FirstGlance]. <br>
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Description: High resolution TMPRSS2 structure following acylation by nafamostat
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GBS:4-GUANIDINOBENZOIC+ACID'>GBS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Hutchinson, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v04 OCA], [https://pdbe.org/8v04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v04 RCSB], [https://www.ebi.ac.uk/pdbsum/8v04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v04 ProSAT]</span></td></tr>
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[[Category: Kutera, M]]
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</table>
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[[Category: Benard, F]]
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== Function ==
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[[Category: Seitova, A]]
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[https://www.uniprot.org/uniprot/TMPS2_HUMAN TMPS2_HUMAN] Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).[UniProtKB:Q9JIQ8]<ref>PMID:15537383</ref> <ref>PMID:25122198</ref> <ref>PMID:26018085</ref> (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.<ref>PMID:21068237</ref> <ref>PMID:21325420</ref> <ref>PMID:23536651</ref> <ref>PMID:23966399</ref> <ref>PMID:24027332</ref> <ref>PMID:24227843</ref> <ref>PMID:32142651</ref> <ref>PMID:32404436</ref>
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[[Category: Dong, A]]
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== References ==
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[[Category: Levon, H]]
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<references/>
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[[Category: Edwards, A]]
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__TOC__
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[[Category: Li, Y]]
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</StructureSection>
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[[Category: Fraser, B.J]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith C]]
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[[Category: Benard F]]
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[[Category: Dong A]]
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[[Category: Edwards A]]
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[[Category: Fraser BJ]]
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[[Category: Hutchinson A]]
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[[Category: Kutera M]]
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[[Category: Levon H]]
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[[Category: Li Y]]
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[[Category: Seitova A]]

Revision as of 11:47, 1 February 2024

High resolution TMPRSS2 structure following acylation by nafamostat

PDB ID 8v04

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