6zt3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:57, 1 February 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='6zt3' size='340' side='right'caption='[[6zt3]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
<StructureSection load='6zt3' size='340' side='right'caption='[[6zt3]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6zt3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZT3 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6zt3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZT3 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gyrB, MSMEG_0005, MSMEI_0007 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zt3 OCA], [https://pdbe.org/6zt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zt3 RCSB], [https://www.ebi.ac.uk/pdbsum/6zt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zt3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zt3 OCA], [https://pdbe.org/6zt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zt3 RCSB], [https://www.ebi.ac.uk/pdbsum/6zt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zt3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/GYRB_MYCS2 GYRB_MYCS2]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner (PubMed:8878580) to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01898]<ref>PMID:8878580</ref>
+
[https://www.uniprot.org/uniprot/GYRB_MYCS2 GYRB_MYCS2] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner (PubMed:8878580) to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01898]<ref>PMID:8878580</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 19:
</div>
</div>
<div class="pdbe-citations 6zt3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6zt3" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
Line 25: Line 27:
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Mycs2]]
+
[[Category: Mycolicibacterium smegmatis MC2 155]]
-
[[Category: Feng, L]]
+
[[Category: Feng L]]
-
[[Category: Lawson, D M]]
+
[[Category: Lawson DM]]
-
[[Category: Maxwell, A]]
+
[[Category: Maxwell A]]
-
[[Category: Mi, K]]
+
[[Category: Mi K]]
-
[[Category: Mitchenall, L A]]
+
[[Category: Mitchenall LA]]
-
[[Category: Mundy, J E.A]]
+
[[Category: Mundy JEA]]
-
[[Category: Stevenson, C E.M]]
+
[[Category: Stevenson CEM]]
-
[[Category: Atpase domain]]
+
-
[[Category: Ghkl superfamily]]
+
-
[[Category: Isomerase]]
+
-
[[Category: Type iia topoisomerase]]
+

Current revision

N-terminal 47 kDa fragment of the Mycobacterium smegmatis DNA Gyrase B subunit complexed with ADPNP

PDB ID 6zt3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6zt3"
Personal tools