6zvd

==14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 96h incubation==

<StructureSection load='6zvd' size='340' side='right'caption='[[6zvd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[6zvd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZVD FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zvd OCA], [https://pdbe.org/6zvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zvd RCSB], [https://www.ebi.ac.uk/pdbsum/6zvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zvd ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

[[Category: Homo sapiens]]

[[Category: Ballone A]]

[[Category: Zweipfenning FPA]]