6zve
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ==== | + | ==14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 1h incubation== |
| - | <StructureSection load='6zve' size='340' side='right'caption='[[6zve]]' scene=''> | + | <StructureSection load='6zve' size='340' side='right'caption='[[6zve]], [[Resolution|resolution]] 2.51Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6zve]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZVE FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zve OCA], [https://pdbe.org/6zve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zve RCSB], [https://www.ebi.ac.uk/pdbsum/6zve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zve ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zve OCA], [https://pdbe.org/6zve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zve RCSB], [https://www.ebi.ac.uk/pdbsum/6zve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zve ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GAB2_HUMAN GAB2_HUMAN] Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.<ref>PMID:15750601</ref> <ref>PMID:19172738</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Ballone A]] |
| + | [[Category: Lau RA]] | ||
| + | [[Category: Ottmann C]] | ||
| + | [[Category: Zweipfenning FPA]] | ||
Revision as of 11:58, 1 February 2024
14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 1h incubation
| |||||||||||
