7a1v
From Proteopedia
(Difference between revisions)
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==Crystal structure of YTHDF2 in complex with m1A== | ==Crystal structure of YTHDF2 in complex with m1A== | ||
| - | <StructureSection load='7a1v' size='340' side='right'caption='[[7a1v]]' scene=''> | + | <StructureSection load='7a1v' size='340' side='right'caption='[[7a1v]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A1V FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7a1v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A1V FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a1v OCA], [https://pdbe.org/7a1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a1v RCSB], [https://www.ebi.ac.uk/pdbsum/7a1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a1v ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M1A:6-AMINO-1-METHYLPURINE'>M1A</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a1v OCA], [https://pdbe.org/7a1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a1v RCSB], [https://www.ebi.ac.uk/pdbsum/7a1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a1v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/YTHD2_HUMAN YTHD2_HUMAN] Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.<ref>PMID:22575960</ref> <ref>PMID:24284625</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Caflisch A]] | [[Category: Caflisch A]] | ||
[[Category: Wang X]] | [[Category: Wang X]] | ||
Current revision
Crystal structure of YTHDF2 in complex with m1A
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