7a5a

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<StructureSection load='7a5a' size='340' side='right'caption='[[7a5a]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
<StructureSection load='7a5a' size='340' side='right'caption='[[7a5a]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7a5a]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A5A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7a5a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Crimean-Congo_hemorrhagic_fever_virus_strain_IbAr10200 Crimean-Congo hemorrhagic fever virus strain IbAr10200]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A5A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.989&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a5a OCA], [https://pdbe.org/7a5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a5a RCSB], [https://www.ebi.ac.uk/pdbsum/7a5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a5a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a5a OCA], [https://pdbe.org/7a5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a5a RCSB], [https://www.ebi.ac.uk/pdbsum/7a5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a5a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GP_CCHFI GP_CCHFI]] Glycoprotein C and glycoprotein N interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion (By similarity).<ref>PMID:19088291</ref>
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[https://www.uniprot.org/uniprot/GP_CCHFI GP_CCHFI] Glycoprotein C and glycoprotein N interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion (By similarity).<ref>PMID:19088291</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Crimean-Congo hemorrhagic fever virus strain IbAr10200]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Guardado-Calvo, P]]
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[[Category: Guardado-Calvo P]]
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[[Category: Hellert, J]]
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[[Category: Hellert J]]
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[[Category: Rey, F A]]
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[[Category: Rey FA]]
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[[Category: Class ii membrane fusion protein]]
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[[Category: Viral protein]]
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[[Category: Virus entry]]
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Revision as of 12:03, 1 February 2024

Crimean-Congo Hemorrhagic Fever Virus Envelope Glycoprotein Gc W1191H/W1197A/W1199A Mutant in Postfusion Conformation (Monoclinic Crystal Form)

PDB ID 7a5a

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