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7a6x

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Current revision (12:04, 1 February 2024) (edit) (undo)
 
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<StructureSection load='7a6x' size='340' side='right'caption='[[7a6x]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
<StructureSection load='7a6x' size='340' side='right'caption='[[7a6x]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7a6x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A6X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7a6x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A6X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R3B:(2S,9S,12R)-2-cyclohexyl-12-[2-(3,4-dimethoxyphenyl)ethyl]-24,27-dimethoxy-11,18,22-trioxa-4-azatetracyclo[21.2.2.113,17.04,9]octacosa-1(25),13(28),14,16,23,26-hexaene-3,10-dione'>R3B</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FKBP5, AIG6, FKBP51 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R3B:(2S,9S,12R)-2-cyclohexyl-12-[2-(3,4-dimethoxyphenyl)ethyl]-24,27-dimethoxy-11,18,22-trioxa-4-azatetracyclo[21.2.2.113,17.04,9]octacosa-1(25),13(28),14,16,23,26-hexaene-3,10-dione'>R3B</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a6x OCA], [https://pdbe.org/7a6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a6x RCSB], [https://www.ebi.ac.uk/pdbsum/7a6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a6x ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a6x OCA], [https://pdbe.org/7a6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a6x RCSB], [https://www.ebi.ac.uk/pdbsum/7a6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a6x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
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[https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7a6x" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7a6x" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[FKBP 3D structures|FKBP 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Bauder M]]
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[[Category: Bauder, M]]
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[[Category: Hausch F]]
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[[Category: Hausch, F]]
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[[Category: Heymann T]]
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[[Category: Heymann, T]]
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[[Category: Merz S]]
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[[Category: Merz, S]]
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[[Category: Meyners C]]
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[[Category: Meyners, C]]
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[[Category: Purder P]]
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[[Category: Purder, P]]
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[[Category: Voll A]]
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[[Category: Voll, A]]
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[[Category: Complex]]
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[[Category: Fkbp]]
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[[Category: Inhibitor]]
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[[Category: Isomerase]]
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[[Category: Safit]]
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Current revision

Structure of the FKBP51FK1 domain in complex with the macrocyclic SAFit analogue 56

PDB ID 7a6x

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