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7acm

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Current revision (12:07, 1 February 2024) (edit) (undo)
 
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<StructureSection load='7acm' size='340' side='right'caption='[[7acm]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
<StructureSection load='7acm' size='340' side='right'caption='[[7acm]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7acm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ACM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ACM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7acm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ACM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ACM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TMO:TRIMETHYLAMINE+OXIDE'>TMO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.763&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rcdA, ybjK, b0846, JW5114 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TMO:TRIMETHYLAMINE+OXIDE'>TMO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7acm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7acm OCA], [https://pdbe.org/7acm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7acm RCSB], [https://www.ebi.ac.uk/pdbsum/7acm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7acm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7acm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7acm OCA], [https://pdbe.org/7acm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7acm RCSB], [https://www.ebi.ac.uk/pdbsum/7acm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7acm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RCDA_ECOLI RCDA_ECOLI]] Regulates the expression of a number of genes involved in biofilm formation and stress response. Target genes include six stress-response transcriptional regulators: csgD, which is a master regulator of biofilm formation, appY, sxy, ycgF, fimB and rcdA itself. This indicates that a large number of genes must be regulated indirectly via these transcriptional regulators. Acts by binding to the upstream region of its target genes.<ref>PMID:23233451</ref>
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[https://www.uniprot.org/uniprot/RCDA_ECOLI RCDA_ECOLI] Regulates the expression of a number of genes involved in biofilm formation and stress response. Target genes include six stress-response transcriptional regulators: csgD, which is a master regulator of biofilm formation, appY, sxy, ycgF, fimB and rcdA itself. This indicates that a large number of genes must be regulated indirectly via these transcriptional regulators. Acts by binding to the upstream region of its target genes.<ref>PMID:23233451</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7acm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7acm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[RcdA|RcdA]]
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cociurovscaia, A]]
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[[Category: Cociurovscaia A]]
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[[Category: Pietrzyk-Brzezinska, A J]]
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[[Category: Pietrzyk-Brzezinska AJ]]
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[[Category: Dna-binding protein]]
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[[Category: Gene regulation]]
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[[Category: Hth motif]]
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[[Category: Transcription factor]]
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Current revision

Crystal structure of E. coli HTH-type transcriptional regulator RcdA in complex with TMAO at 1.76 A resolution

PDB ID 7acm

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