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7aro

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Current revision (12:14, 1 February 2024) (edit) (undo)
 
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<StructureSection load='7aro' size='340' side='right'caption='[[7aro]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
<StructureSection load='7aro' size='340' side='right'caption='[[7aro]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7aro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ARO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ARO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7aro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ARO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ARO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=RVZ:2-azanyl-6-(1~{H}-imidazol-2-ylmethylsulfanyl)-4-phenyl-pyridine-3,5-dicarbonitrile'>RVZ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.119&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADORA2A, ADORA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=RVZ:2-azanyl-6-(1~{H}-imidazol-2-ylmethylsulfanyl)-4-phenyl-pyridine-3,5-dicarbonitrile'>RVZ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aro OCA], [https://pdbe.org/7aro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aro RCSB], [https://www.ebi.ac.uk/pdbsum/7aro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aro ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aro OCA], [https://pdbe.org/7aro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aro RCSB], [https://www.ebi.ac.uk/pdbsum/7aro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aro ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN]] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7aro" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7aro" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Adenosine A2A receptor 3D structures|Adenosine A2A receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Amelia, T]]
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[[Category: Amelia T]]
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[[Category: Cheng, R]]
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[[Category: Cheng R]]
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[[Category: Cooke, R]]
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[[Category: Cooke R]]
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[[Category: Es, D van der]]
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[[Category: Falsini M]]
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[[Category: Falsini, M]]
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[[Category: Heitman L]]
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[[Category: Heitman, L]]
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[[Category: Ijzerman A]]
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[[Category: Ijzerman, A]]
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[[Category: Liu R]]
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[[Category: Liu, R]]
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[[Category: Segala E]]
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[[Category: Segala, E]]
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[[Category: Verdon G]]
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[[Category: Veldhoven, J van]]
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[[Category: Van Veldhoven J]]
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[[Category: Verdon, G]]
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[[Category: Van Westen G]]
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[[Category: Westen, G van]]
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[[Category: Van der Es D]]
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[[Category: G protein-coupled receptor]]
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[[Category: Gpcr]]
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[[Category: Membrane protein]]
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[[Category: Partial agonist]]
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[[Category: Receptor]]
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Current revision

Crystal structure of the non-ribose partial agonist LUF5833 bound to the adenosine A2A receptor

PDB ID 7aro

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