7nlc
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide== |
| - | <StructureSection load='7nlc' size='340' side='right'caption='[[7nlc]]' scene=''> | + | <StructureSection load='7nlc' size='340' side='right'caption='[[7nlc]], [[Resolution|resolution]] 1.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7nlc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Orthohepevirus_A Orthohepevirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NLC FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nlc OCA], [https://pdbe.org/7nlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nlc RCSB], [https://www.ebi.ac.uk/pdbsum/7nlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nlc ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.398Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nlc OCA], [https://pdbe.org/7nlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nlc RCSB], [https://www.ebi.ac.uk/pdbsum/7nlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nlc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref> <ref>PMID:17853893</ref> <ref>PMID:17556548</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Tumor susceptibility gene 101|Tumor susceptibility gene 101]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Orthohepevirus A]] |
| + | [[Category: Dupre E]] | ||
| + | [[Category: Hanoulle X]] | ||
| + | [[Category: Moschidi D]] | ||
| + | [[Category: Villeret V]] | ||
Current revision
Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide
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