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1pvs

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[[Image:1pvs.gif|left|200px]]
[[Image:1pvs.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1pvs |SIZE=350|CAPTION= <scene name='initialview01'>1pvs</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1pvs", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=7HP:7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE'>7HP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_II DNA-3-methyladenine glycosylase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.21 3.2.2.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ALKA OR AIDA OR B2068 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1pvs| PDB=1pvs | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pvs OCA], [http://www.ebi.ac.uk/pdbsum/1pvs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pvs RCSB]</span>
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}}
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'''3-methyladenine Glcosylase II(AlkA) Hypoxanthine complex'''
'''3-methyladenine Glcosylase II(AlkA) Hypoxanthine complex'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Teale, M.]]
[[Category: Teale, M.]]
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[[Category: alka]]
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[[Category: Alka]]
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[[Category: dna glycosylase]]
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[[Category: Dna glycosylase]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: hypoxanthine]]
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[[Category: Hypoxanthine]]
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[[Category: reaction-product complex]]
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[[Category: Reaction-product complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:32:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:05:13 2008''
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Revision as of 02:32, 3 May 2008

Image:1pvs.gif

Template:STRUCTURE 1pvs

3-methyladenine Glcosylase II(AlkA) Hypoxanthine complex


Overview

Escherichia coli (E. coli) protein 3-methyladenine-DNA glycosylase II (AlkA) functions primarily by removing alkylation damage from duplex and single stranded DNA. A crystal structure of AlkA was refined to 2.0 A resolution. This structure in turn was used to refine an AlkA-hypoxanthine (substrate) complex structure to 2.4 A resolution. The complex structure shows hypoxanthine located in AlkA's active site stacked between residues W218 and Y239. The structural analysis of the AlkA and AlkA-hypoxanthine structures indicate that free hypoxanthine binding in the active site may inhibit glycosylase activity.

About this Structure

1PVS is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

3-methyladenine-DNA glycosylase II: the crystal structure of an AlkA-hypoxanthine complex suggests the possibility of product inhibition., Teale M, Symersky J, DeLucas L, Bioconjug Chem. 2002 May-Jun;13(3):403-7. PMID:12009927 Page seeded by OCA on Sat May 3 05:32:36 2008

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