7ogu

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Current revision (12:50, 1 February 2024) (edit) (undo)
 
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==Plant peptide hormone receptor complex H1C9S1==
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<StructureSection load='7ogu' size='340' side='right'caption='[[7ogu]]' scene=''>
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<StructureSection load='7ogu' size='340' side='right'caption='[[7ogu]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7ogu]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OGU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OGU FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ogu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ogu OCA], [https://pdbe.org/7ogu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ogu RCSB], [https://www.ebi.ac.uk/pdbsum/7ogu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ogu ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.872&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ogu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ogu OCA], [https://pdbe.org/7ogu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ogu RCSB], [https://www.ebi.ac.uk/pdbsum/7ogu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ogu ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HSL1_ARATH HSL1_ARATH]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The membrane receptor kinases HAESA and HSL2 recognize a family of IDA/IDL signaling peptides to control cell separation processes in different plant organs. The homologous HSL1 has been reported to regulate epidermal cell patterning by interacting with a different class of signaling peptides from the CLE family. Here we demonstrate that HSL1 binds IDA/IDL peptides with high, and CLE peptides with lower affinity, respectively. Ligand sensing capability and receptor activation of HSL1 require a SERK co-receptor kinase. Crystal structures with IDA/IDLs or with CLE9 reveal that HSL1-SERK1 complex recognizes the entire IDA/IDL signaling peptide, while only parts of CLE9 are bound to the receptor. In contrast, the receptor kinase BAM1 interacts with the entire CLE9 peptide with high affinity and specificity. Furthermore, the receptor tandem BAM1/BAM2 regulates epidermal cell division homeostasis. Consequently, HSL1-IDLs and BAM1/BAM2-CLEs independently regulate cell patterning in the leaf epidermal tissue.
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HSL1 and BAM1/2 impact epidermal cell development by sensing distinct signaling peptides.,Roman AO, Jimenez-Sandoval P, Augustin S, Broyart C, Hothorn LA, Santiago J Nat Commun. 2022 Feb 15;13(1):876. doi: 10.1038/s41467-022-28558-4. PMID:35169143<ref>PMID:35169143</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7ogu" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Jimenez-Sandoval P]]
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[[Category: Roman AO]]
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[[Category: Santiago J]]

Current revision

Plant peptide hormone receptor complex H1C9S1

PDB ID 7ogu

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