7oqu

==Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ180==

<StructureSection load='7oqu' size='340' side='right'caption='[[7oqu]], [[Resolution|resolution]] 1.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[7oqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OQU FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oqu OCA], [https://pdbe.org/7oqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oqu RCSB], [https://www.ebi.ac.uk/pdbsum/7oqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oqu ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

==See Also==

*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]

[[Category: Homo sapiens]]

[[Category: Centorrino F]]

[[Category: Ottmann C]]