7oqw

==Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ178==

<StructureSection load='7oqw' size='340' side='right'caption='[[7oqw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>

<table><tr><td colspan='2'>[[7oqw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OQW FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oqw OCA], [https://pdbe.org/7oqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oqw RCSB], [https://www.ebi.ac.uk/pdbsum/7oqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oqw ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

==See Also==

*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]

[[Category: Homo sapiens]]

[[Category: Centorrino F]]

[[Category: Ottmann C]]