1pwy

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[[Image:1pwy.jpg|left|200px]]
[[Image:1pwy.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1pwy |SIZE=350|CAPTION= <scene name='initialview01'>1pwy</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1pwy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AC2:9-HYROXYETHOXYMETHYLGUANINE'>AC2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1pwy| PDB=1pwy | SCENE= }}
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|RELATEDENTRY=[[1m73|1M73]], [[1pf7|1PF7]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwy OCA], [http://www.ebi.ac.uk/pdbsum/1pwy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pwy RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HUMAN PNP COMPLEXED WITH ACYCLOVIR'''
'''CRYSTAL STRUCTURE OF HUMAN PNP COMPLEXED WITH ACYCLOVIR'''
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[[Category: Santos, D S.]]
[[Category: Santos, D S.]]
[[Category: Silva, R G.]]
[[Category: Silva, R G.]]
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[[Category: acyclovir]]
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[[Category: Acyclovir]]
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[[Category: crystallography]]
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[[Category: Crystallography]]
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[[Category: drug design]]
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[[Category: Drug design]]
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[[Category: purine nucleoside phosphorylase]]
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[[Category: Purine nucleoside phosphorylase]]
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[[Category: synchrotron]]
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[[Category: Synchrotron]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:35:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:05:43 2008''
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Revision as of 02:35, 3 May 2008

Image:1pwy.jpg

Template:STRUCTURE 1pwy

CRYSTAL STRUCTURE OF HUMAN PNP COMPLEXED WITH ACYCLOVIR


Overview

In human, purine nucleoside phosphorylase (HsPNP) is responsible for degradation of deoxyguanosine and genetic deficiency of this enzyme leads to profound T-cell mediated immunosuppression. PNP is therefore a target for inhibitor development aiming at T-cell immune response modulation and has been submitted to extensive structure-based drug design. This work reports the first crystallographic study of human PNP complexed with acyclovir (HsPNP:Acy). Acyclovir is a potent clinically useful inhibitor of replicant herpes simplex virus that also inhibits human PNP but with a relatively lower inhibitory activity (K(i)=90 microM). Analysis of the structural differences among the HsPNP:Acy complex, PNP apoenzyme, and HsPNP:Immucillin-H provides explanation for inhibitor binding, refines the purine-binding site, and can be used for future inhibitor design.

About this Structure

1PWY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir., dos Santos DM, Canduri F, Pereira JH, Vinicius Bertacine Dias M, Silva RG, Mendes MA, Palma MS, Basso LA, de Azevedo WF Jr, Santos DS, Biochem Biophys Res Commun. 2003 Aug 29;308(3):553-9. PMID:12914786 Page seeded by OCA on Sat May 3 05:35:00 2008

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