7qie

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Current revision (13:18, 1 February 2024) (edit) (undo)
 
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<StructureSection load='7qie' size='340' side='right'caption='[[7qie]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
<StructureSection load='7qie' size='340' side='right'caption='[[7qie]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7qie]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QIE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7qie]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QIE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DVF:5-methyl-2-(2-propan-2-ylphenyl)-~{N}-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-4-amine'>DVF</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/1-phosphatidylinositol-5-phosphate_4-kinase 1-phosphatidylinositol-5-phosphate 4-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.149 2.7.1.149] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DVF:5-methyl-2-(2-propan-2-ylphenyl)-~{N}-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-4-amine'>DVF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qie OCA], [https://pdbe.org/7qie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qie RCSB], [https://www.ebi.ac.uk/pdbsum/7qie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qie ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qie OCA], [https://pdbe.org/7qie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qie RCSB], [https://www.ebi.ac.uk/pdbsum/7qie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qie ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PI42C_HUMAN PI42C_HUMAN]] May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.
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[https://www.uniprot.org/uniprot/PI42C_HUMAN PI42C_HUMAN] May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 1-phosphatidylinositol-5-phosphate 4-kinase]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Howard, T D]]
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[[Category: Howard TD]]
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[[Category: Ogg, D T]]
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[[Category: Ogg DT]]
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[[Category: Allosteric binding]]
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[[Category: Lipid kinase]]
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[[Category: Non-atp-competitive inhibitor]]
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[[Category: Phosphatidylinositol 5-phosphate]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor

PDB ID 7qie

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OCA

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