7qs0
From Proteopedia
(Difference between revisions)
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==Crystal structure of B30.2 PRYSPRY domain of TRIM10== | ==Crystal structure of B30.2 PRYSPRY domain of TRIM10== | ||
| - | <StructureSection load='7qs0' size='340' side='right'caption='[[7qs0]]' scene=''> | + | <StructureSection load='7qs0' size='340' side='right'caption='[[7qs0]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QS0 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7qs0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QS0 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qs0 OCA], [https://pdbe.org/7qs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qs0 RCSB], [https://www.ebi.ac.uk/pdbsum/7qs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qs0 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qs0 OCA], [https://pdbe.org/7qs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qs0 RCSB], [https://www.ebi.ac.uk/pdbsum/7qs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qs0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRI10_HUMAN TRI10_HUMAN] E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (PubMed:33811647).[UniProtKB:Q9WUH5]<ref>PMID:33811647</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chaikuad A]] | [[Category: Chaikuad A]] | ||
[[Category: Knapp S]] | [[Category: Knapp S]] | ||
Revision as of 13:21, 1 February 2024
Crystal structure of B30.2 PRYSPRY domain of TRIM10
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