7qs2
From Proteopedia
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==Crystal structure of B30.2 PRYSPRY domain of TRIM15== | ==Crystal structure of B30.2 PRYSPRY domain of TRIM15== | ||
| - | <StructureSection load='7qs2' size='340' side='right'caption='[[7qs2]]' scene=''> | + | <StructureSection load='7qs2' size='340' side='right'caption='[[7qs2]], [[Resolution|resolution]] 1.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QS2 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7qs2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QS2 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qs2 OCA], [https://pdbe.org/7qs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qs2 RCSB], [https://www.ebi.ac.uk/pdbsum/7qs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qs2 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qs2 OCA], [https://pdbe.org/7qs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qs2 RCSB], [https://www.ebi.ac.uk/pdbsum/7qs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qs2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRI15_HUMAN TRI15_HUMAN] E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis (PubMed:34142270, PubMed:23077300). Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN (PubMed:25015296). Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS (PubMed:23077300). Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm (PubMed:34871740). Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs).<ref>PMID:23077300</ref> <ref>PMID:25015296</ref> <ref>PMID:34142270</ref> <ref>PMID:34497368</ref> <ref>PMID:34871740</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chaikuad A]] | [[Category: Chaikuad A]] | ||
[[Category: Knapp S]] | [[Category: Knapp S]] | ||
[[Category: Zhubi R]] | [[Category: Zhubi R]] | ||
Revision as of 13:22, 1 February 2024
Crystal structure of B30.2 PRYSPRY domain of TRIM15
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