7qs3
From Proteopedia
(Difference between revisions)
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==Crystal structure of B30.2 PRYSPRY domain of TRIM16== | ==Crystal structure of B30.2 PRYSPRY domain of TRIM16== | ||
| - | <StructureSection load='7qs3' size='340' side='right'caption='[[7qs3]]' scene=''> | + | <StructureSection load='7qs3' size='340' side='right'caption='[[7qs3]], [[Resolution|resolution]] 1.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QS3 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7qs3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QS3 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qs3 OCA], [https://pdbe.org/7qs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qs3 RCSB], [https://www.ebi.ac.uk/pdbsum/7qs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qs3 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qs3 OCA], [https://pdbe.org/7qs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qs3 RCSB], [https://www.ebi.ac.uk/pdbsum/7qs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qs3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRI16_HUMAN TRI16_HUMAN] E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.<ref>PMID:22629402</ref> <ref>PMID:27693506</ref> <ref>PMID:30143514</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chaikuad A]] | [[Category: Chaikuad A]] | ||
[[Category: Knapp S]] | [[Category: Knapp S]] | ||
[[Category: Zhubi R]] | [[Category: Zhubi R]] | ||
Revision as of 13:22, 1 February 2024
Crystal structure of B30.2 PRYSPRY domain of TRIM16
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