7r3n
From Proteopedia
(Difference between revisions)
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==mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 3== | ==mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 3== | ||
| - | <StructureSection load='7r3n' size='340' side='right'caption='[[7r3n]]' scene=''> | + | <StructureSection load='7r3n' size='340' side='right'caption='[[7r3n]], [[Resolution|resolution]] 3.16Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R3N FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7r3n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R3N FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r3n OCA], [https://pdbe.org/7r3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r3n RCSB], [https://www.ebi.ac.uk/pdbsum/7r3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r3n ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.16Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r3n OCA], [https://pdbe.org/7r3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r3n RCSB], [https://www.ebi.ac.uk/pdbsum/7r3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r3n ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IL12B_MOUSE IL12B_MOUSE] Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.<ref>PMID:11114383</ref> | ||
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| + | ==See Also== | ||
| + | *[[Interleukin 3D structures|Interleukin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
[[Category: Bloch Y]] | [[Category: Bloch Y]] | ||
[[Category: Savvides SN]] | [[Category: Savvides SN]] | ||
Revision as of 13:25, 1 February 2024
mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 3
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