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7zeh

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Current revision (13:31, 1 February 2024) (edit) (undo)
 
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<StructureSection load='7zeh' size='340' side='right'caption='[[7zeh]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='7zeh' size='340' side='right'caption='[[7zeh]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7zeh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7zeh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IPQ:N7-(3,4-difluorobenzyl)+guanine'>IPQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RBL:D-RIBULOSE'>RBL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IPQ:N7-(3,4-difluorobenzyl)+guanine'>IPQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RBL:D-RIBULOSE'>RBL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zeh OCA], [https://pdbe.org/7zeh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zeh RCSB], [https://www.ebi.ac.uk/pdbsum/7zeh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zeh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zeh OCA], [https://pdbe.org/7zeh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zeh RCSB], [https://www.ebi.ac.uk/pdbsum/7zeh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zeh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/5NT3B_HUMAN 5NT3B_HUMAN]] Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233).<ref>PMID:23223233</ref> <ref>PMID:24603684</ref>
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[https://www.uniprot.org/uniprot/5NT3B_HUMAN 5NT3B_HUMAN] Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233).<ref>PMID:23223233</ref> <ref>PMID:24603684</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Baranowski, M R]]
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[[Category: Baranowski MR]]
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[[Category: Basquin, J]]
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[[Category: Basquin J]]
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[[Category: Jemielity, J]]
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[[Category: Jemielity J]]
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[[Category: Kowalska, J]]
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[[Category: Kowalska J]]
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[[Category: Kozarski, M]]
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[[Category: Kozarski M]]
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[[Category: Kubacka, D]]
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[[Category: Kubacka D]]
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[[Category: Wojcik, R]]
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[[Category: Wojcik R]]
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[[Category: Cytosolic 5' nucleotidase]]
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[[Category: Hydrolase]]
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[[Category: Mrna cap degradation]]
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[[Category: N7 methylguanosine monophosphate dephosphorylation]]
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Current revision

Human cytosolic 5' nucleotidase IIIB in complex with 3,4-diF-Bn7Guanine

PDB ID 7zeh

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