2ygb

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Current revision (14:04, 1 February 2024) (edit) (undo)
 
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<StructureSection load='2ygb' size='340' side='right'caption='[[2ygb]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
<StructureSection load='2ygb' size='340' side='right'caption='[[2ygb]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ygb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_western_reserve Vaccinia virus western reserve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YGB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ygb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_Western_Reserve Vaccinia virus Western Reserve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YGB FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ygb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygb OCA], [https://pdbe.org/2ygb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ygb RCSB], [https://www.ebi.ac.uk/pdbsum/2ygb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ygb ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ygb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygb OCA], [https://pdbe.org/2ygb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ygb RCSB], [https://www.ebi.ac.uk/pdbsum/2ygb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ygb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/D13_VACCW D13_VACCW]] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus.
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[https://www.uniprot.org/uniprot/D13_VACCW D13_VACCW] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Vaccinia virus western reserve]]
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[[Category: Vaccinia virus Western Reserve]]
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[[Category: Bahar, M W]]
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[[Category: Bahar MW]]
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[[Category: Graham, S C]]
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[[Category: Graham SC]]
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[[Category: Grimes, J M]]
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[[Category: Grimes JM]]
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[[Category: Stuart, D I]]
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[[Category: Stuart DI]]
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[[Category: Viral evolution]]
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[[Category: Viral protein]]
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Current revision

Structure of vaccinia virus D13 scaffolding protein

PDB ID 2ygb

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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